BDBM50036484 5-((E)-Styryl)-quinazoline-2,4-diamine::CHEMBL164845

SMILES Nc1nc(N)c2c(\C=C\c3ccccc3)cccc2n1

InChI Key InChIKey=YPIDSPOROIRHIL-MDZDMXLPSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50036484   

TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036484(5-((E)-Styryl)-quinazoline-2,4-diamine | CHEMBL164...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036484(5-((E)-Styryl)-quinazoline-2,4-diamine | CHEMBL164...)
Affinity DataKi:  5.40nMAssay Description:Inhibitory compound against Wild-type human DHFR.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036484(5-((E)-Styryl)-quinazoline-2,4-diamine | CHEMBL164...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036484(5-((E)-Styryl)-quinazoline-2,4-diamine | CHEMBL164...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036484(5-((E)-Styryl)-quinazoline-2,4-diamine | CHEMBL164...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed