BDBM50044673 CHEMBL3353353::US10358436, Example A167
SMILES CCc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1
InChI Key
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50044673
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair