BDBM50060426 CHEMBL296161::Dimethyl-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-amine::L-741604

SMILES CN(C)CCc1c[nH]c2ccc(cc12)-n1cnnc1

InChI Key InChIKey=IGNXHSPBUUSUHB-UHFFFAOYSA-N

Data  12 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50060426   

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataEC50:  0.450nMAssay Description:Measurement of agonist induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for its ability to displace [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]-5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataEC50:  0.400nMAssay Description:Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataEC50:  0.400nMAssay Description:Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its ability to displace [3H]DOB from 5-hydroxytryptamine 2A receptor in rat cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  0.430nMAssay Description:Compound was tested for its ability to displace [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  52nMAssay Description:Compound was tested for its ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in pig cortexMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  3.10E+3nMAssay Description:Compound was tested for its ability to displace [3H]mesulergine from 5-hydroxytryptamine 2C receptor in pig cortexMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)TBA
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its ability to displace [3H]-Q-ICS 205-930 from 5-hydroxytryptamine 3 receptor in rat cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060426(CHEMBL296161 | Dimethyl-[2-(5-[1,2,4]triazol-4-yl-...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed