BDBM50063993 5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidine-2,4-diamine::5-(Naphthalen-2-ylsulfanylmethyl)-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL283311

SMILES Nc1nc(N)c2c(CSc3ccc4ccccc4c3)coc2n1

InChI Key InChIKey=YGXJSXPQWMYNEJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50063993   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against dihydrofolate reductase from pneumocystis carniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  650nMAssay Description:Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  650nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063993(5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed