BDBM50087011 8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL280827

SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=PYQRZQXALHGAGL-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50087011   

TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  1.40nMAssay Description:Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  32nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  44nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  460nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataEC50:  510nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087011(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataEC50:  3.70E+3nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to mu1 receptor was determined using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed