BDBM50128789 4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-pyridin-3-ylmethyl-piperidin-2-one::CHEMBL432934

SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O

InChI Key InChIKey=PHQUSKHDKPDYRN-XDQLBQEWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50128789   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50128789(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Affinity DataIC50:  950nMAssay Description:Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50128789(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Affinity DataIC50:  950nMAssay Description:Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50128789(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed