BDBM50135452 (2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl-3-isopropyl-phenyl]-3-methyl-octa-2,4,6-trienoic acid::CHEMBL130317

SMILES CC(C)c1cc(cc(\C(C)=C/C=C/C(/C)=C/C(O)=O)c1OCC(F)F)-c1ccco1

InChI Key InChIKey=IIGXFBSZCFYBHM-JCBBLABWSA-N

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50135452   

TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135452((2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl...)
Affinity DataKi:  3nMAssay Description:Binding affinity against RXR alpha receptor using [3H]-9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135452((2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-ATRA from RAR gamma receptor in CV-1 cells; Not testedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135452((2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl...)
Affinity DataIC50:  3.60nMAssay Description:In vitro agonistic activity against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135452((2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl...)
Affinity DataEC50:  37nMAssay Description:In vitro agonist efficacy against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135452((2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl...)
Affinity DataEC50:  7.40nMAssay Description:In vitro agonistic activity against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed