BDBM50140380 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-aminomethyl-3-fluoro-biphenyl-4-yl)-amide::CHEMBL20934

SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2CN)n(n1)-c1cc2ccccc2cc1F

InChI Key InChIKey=YXSYVMVOVUKREN-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50140380   

TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory concentration against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against tissue type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against activated protein C (aPC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140380(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed