BDBM50149910 CHEMBL3769561::US10273223, Compound B-153::US9637472, Compound B-153

SMILES Cc1cc(C)c(CNC(=O)c2cc(nc3n(C)ncc23)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1

InChI Key InChIKey=MYAWTCZOHZPHSF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149910   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149910(CHEMBL3769561 | US10273223, Compound B-153 | US963...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149910(CHEMBL3769561 | US10273223, Compound B-153 | US963...)
Affinity DataIC50:  3.00E+4nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149910(CHEMBL3769561 | US10273223, Compound B-153 | US963...)
Affinity DataIC50:  3.00E+4nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent