BDBM50159970 8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-phenyl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione::CHEMBL361826

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCc2noc(n2)-c2ccccc2OC)cc1

InChI Key InChIKey=JNJWKLSCJORTLT-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50159970   

TargetAdenosine receptor A3(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  5nMAssay Description:Binding affinity against Adenosine A3 receptor by displacement of specific binding of [125I]-AB-MECA in membranes prepared from CHO-A3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  9nMAssay Description:Binding affinity against Adenosine A1 receptor labeled by [3H]-CPX in membranes prepared from Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  23nMAssay Description:Binding affinity against Adenosine A2a receptor labeled by [3H]-ZM-241,385 in membranes prepared from HEK-A2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  127nMAssay Description:Binding affinity against Adenosine A2b receptor labeled by [3H]-ZM-241,385 in membranes prepared from HEK-A2B cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  127nMAssay Description:Binding affinity for adenosine A2b receptor by using as [3H]-ZM-241,385 (14 nM) radioligand in membranes from HEK-A2B cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  1.16E+3nMAssay Description:Binding affinity for adenosine A1 receptor by using as [3H]-CPX (0.5 nM) radioligand in membranes from Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50159970(8-{4-[5-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylme...)
Affinity DataKi:  2.94E+3nMAssay Description:Binding affinity for adenosine A2a receptor by using as [3H]-ZM-241,385 (2 nM) radioligand in membranes from HEK-A2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed