BDBM50172467 1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-4-yl]-cyclopropanecarboxylic acid::CHEMBL372751

SMILES CC1(C)CCC(CC1)c1ccc(cc1)-c1ccc(cc1F)C1(CC1)C(O)=O

InChI Key InChIKey=CCTCISPYUXWOGO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50172467   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  1.01E+5nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  8.40E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed