BDBM50180256 1-((R)-2-aminopropyl)-1H-indazol-6-ol::CHEMBL437314

SMILES C[C@@H](N)Cn1ncc2ccc(O)cc12

InChI Key InChIKey=WBYHTZYHAFNBKW-SSDOTTSWSA-N

Data  3 KI  1 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50180256   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataKi:  105nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  5.66E+3nMAssay Description:Activity at adrenergic alpha2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  2.89E+3nMAssay Description:Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  4.71E+3nMAssay Description:Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  1.99E+3nMAssay Description:Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  236nMAssay Description:Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  87nMAssay Description:Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(RAT)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50:  85nMAssay Description:Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180256(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed