BDBM50181395 1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-D-prolineamide::CHEMBL202225
SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1CCCN1Cc1ccccc1
InChI Key InChIKey=SXKJNRIJMAGHAV-AREMUKBSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50181395
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 950nMAssay Description:Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair