BDBM50187381 CHEMBL209324::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methylbenzenesulfonamide

SMILES COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1

InChI Key InChIKey=YMFRPPUSWRHMPF-UHFFFAOYSA-N

Data  7 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50187381   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  30nMAssay Description:Binding affinity to 5HT7 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  53nMAssay Description:Binding affinity to 5HT2B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  200nMAssay Description:Binding affinity to 5HT transporter by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  490nMAssay Description:Binding affinity to 5HT2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of hERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataEC50:  21nMAssay Description:Activity against 5HT1A receptor by Gi-[35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187381(CHEMBL209324 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed