BDBM50188266 7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole::CHEMBL213743

SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1

InChI Key InChIKey=OLLCPXMBOYVHAF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50188266   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of FLT4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PDGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cMet by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  180nMAssay Description:Inhibition of KDR at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  145nMAssay Description:Inhibition of cKit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  970nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  180nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  4.78E+4nMAssay Description:Inhibition of Tie2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed