BDBM50188294 (R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol-4-yl)-biphenyl-3-yl]-pentanoic acid cyanomethyl-amide::CHEMBL213194

SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1cccc(c1)-c1csc(CN2CCNCC2)n1

InChI Key InChIKey=GGQXMEFMGFPZJK-RUZDIDTESA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50188294   

TargetCathepsin K(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188294((R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188294((R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol...)
Affinity DataKi:  680nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188294((R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188294((R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol...)
Affinity DataKi:  5.10E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed