BDBM50188811 (R)-4-(4-fluoro-phenyl)-8-[(1S,2S)-2-(4-fluoro-phenyl)-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL212820

SMILES Fc1ccc(cc1)[C@H]1CNC(=O)C11CCN(CC1)[C@H]1CCCC[C@H]1c1ccc(F)cc1

InChI Key InChIKey=YUWXDNRDMDDSJC-VXNXHJTFSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50188811   

TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188811((R)-4-(4-fluoro-phenyl)-8-[(1S,2S)-2-(4-fluoro-phe...)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188811((R)-4-(4-fluoro-phenyl)-8-[(1S,2S)-2-(4-fluoro-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188811((R)-4-(4-fluoro-phenyl)-8-[(1S,2S)-2-(4-fluoro-phe...)
Affinity DataEC50:  8.36E+3nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed