BDBM50226449 2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpyrimidin-4(3H)-one::CHEMBL393501

SMILES Cn1c(N)nc(CCc2cccc(c2)-c2ccccc2)cc1=O

InChI Key InChIKey=OJPMWSXHQIEAMR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50226449   

TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed