BDBM50250665 CHEMBL4076264::US10961200, Compound 425::US11247971, Cmpd ID 425

SMILES OC(=O)c1csc(n1)-n1nc(cc1O)-c1ccc(F)cc1

InChI Key InChIKey=DTOIPNVKTYNDGF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250665   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250665(CHEMBL4076264 | US10961200, Compound 425 | US11247...)
Affinity DataIC50: >5.70E+4nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250665(CHEMBL4076264 | US10961200, Compound 425 | US11247...)
Affinity DataIC50: >5.70E+4nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250665(CHEMBL4076264 | US10961200, Compound 425 | US11247...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed