BDBM50314076 5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine::CHEMBL1093099::US9422297, AAG-148-43

SMILES Nc1nc(N)c2c(n1)[nH]c1cccc(Sc3ccccc3)c21

InChI Key InChIKey=DXZCXZCCPLYVDG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50314076   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  540nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThymidylate synthase(Escherichia coli)
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibition of VEGFR1 in human A498 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of Flt3 activity in human MV 3:11 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Ghost

US Patent
LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of EGFR in human A431 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed