BDBM50314076 5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine::CHEMBL1093099::US9422297, AAG-148-43
SMILES Nc1nc(N)c2c(n1)[nH]c1cccc(Sc3ccccc3)c21
InChI Key InChIKey=DXZCXZCCPLYVDG-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50314076
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of VEGFR1 in human A498 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 4.12E+4nMAssay Description:Inhibition of Flt3 activity in human MV 3:11 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Ghost
US Patent
Duquesne University of The Holy Ghost
US Patent
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of EGFR in human A431 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair