BDBM50321893 (Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-3-phenyl-urea::CHEMBL1173482

SMILES O=C(Nc1ccccc1)Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1

InChI Key InChIKey=BFAFTEXTXVWPSX-BOPFTXTBSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50321893   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human FLT3 phosphorylation in HUVEC cells after 24 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human cKIT phosphorylation in HUVEC cells after 24 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human KDR phosphorylation in HUVEC cells after 24 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50:  22nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human PDGFRbeta phosphorylation in HUVEC cells after 24 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50321893((Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihyd...)
Affinity DataIC50: <1nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed