BDBM50327948 CHEMBL1257998::trans-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine

SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Nc3nc4cccc(Cl)c4o3)cc2)c2c(N)ncnc12

InChI Key InChIKey=DLQXAWIVHRHOQT-MEMLXQNLSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50327948   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  340nMAssay Description:Inhibition of ERBb2 phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of EGFR phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EGFR phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  12.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50327948(CHEMBL1257998 | trans-N-(4-(4-amino-1-(4-(4-methyl...)
Affinity DataIC50:  207nMAssay Description:Inhibition of IGF1R phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed