BDBM50334058 (3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol::CHEMBL1644765

SMILES C[C@@H]1[C@H](O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12

InChI Key InChIKey=YFJZCMOHVUUOJJ-YUNKPMOVSA-N

Data  4 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50334058   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataKi:  10nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataKi:  400nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataEC50:  370nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334058((3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetrame...)
Affinity DataIC50:  24nMAssay Description:Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed