BDBM50340513 2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridine::CHEMBL1762148

SMILES COc1cc2c(cn(C)c2cc1OC)-c1cc2cccnc2[nH]1

InChI Key InChIKey=GZRCWJUTTURNJO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50340513   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  34nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  34nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  33nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  145nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  180nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  55nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  35nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed