BDBM50351547 CHEMBL1223751

SMILES CCOc1ccc(OCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3Cl)c2C)cc1

InChI Key InChIKey=UOKIJOWYTBNPIM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50351547   

TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Colorado At Boulder

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as probeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
University Of Colorado At Boulder

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  2.78E+4nMAssay Description:Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Colorado At Boulder

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as probeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Colorado At Boulder

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as probeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
School of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  3.42E+4nMAssay Description:Antagonist activity at human TLR4 expressed in HEK blue cells coexpressing MD-2/CD14 assessed as inhibition of LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
School of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  1.11E+5nMAssay Description:Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-8 release preincubated for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
School of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  3.16E+5nMAssay Description:Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release preincubated for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
School of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  3.18E+5nMAssay Description:Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release preincubated for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Colorado At Boulder

Curated by ChEMBL
LigandPNGBDBM50351547(CHEMBL1223751)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as probeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed