BDBM50358932 CHEMBL1923701

SMILES COc1ccc2nc([nH]c2c1)-c1cc(cc(c1)C(=O)N[C@@H](C)c1ccccc1)N(C)S(C)(=O)=O

InChI Key InChIKey=YYFIEQLEVGNNBQ-INIZCTEOSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50358932   

TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358932(CHEMBL1923701)
Affinity DataKi:  525nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by Michaelis menton equationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358932(CHEMBL1923701)
Affinity DataKi:  2.35E+3nMAssay Description:Inhibition of BACE2 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by Michaelis menton equationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358932(CHEMBL1923701)
Affinity DataIC50:  545nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358932(CHEMBL1923701)
Affinity DataIC50:  2.43E+3nMAssay Description:Inhibition of BACE2 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed