BDBM50386859 CHEMBL2048293

SMILES OC(=O)CC1CCn2c1cc1cc(ccc21)-c1noc(n1)-c1cc(OC(F)(F)F)cc(c1)C#N

InChI Key InChIKey=HHVPFOZVFPAJBT-UHFFFAOYSA-N

Data  7 IC50  17 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50386859   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity against human S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  0.760nMAssay Description:Agonist activity against human S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity against mouse S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity against mouse S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  123nMAssay Description:Agonist activity against human S1P1 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  123nMAssay Description:Agonist activity against human S1P1 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P2 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P3 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P3 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P4 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P4 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  289nMAssay Description:Agonist activity against human S1P5 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  289nMAssay Description:Agonist activity against human S1P5 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against human S1P2 by beta arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by astemizole assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386859(CHEMBL2048293)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity against human S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed