BDBM50396615 CHEMBL2171928::US8765940, 4-(1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-6-methyl-2-pyrimidinamine

SMILES Cc1cc(nc(N)n1)-c1ccc2c(c1)N(CC2(C)C)c1c(C)c(nc2cc(F)ccc12)-c1ccccn1

InChI Key InChIKey=QYVBQWFPPJZFHA-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50396615   

LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  364nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  449nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  449nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi: >1.25E+5nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi: >1.25E+5nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed