BDBM50397732 CHEMBL2181983

SMILES Brc1ccc2SCCC(OC(=O)[C@H]3C[C@]4(CN3)C(=O)Nc3ccccc43)c2c1

InChI Key InChIKey=OPUJSFZMYKHRTH-RZSJKOKISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397732   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397732(CHEMBL2181983)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of human recombinant BACE1 using RGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGA as substrate after 1 hr by TMB-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50397732(CHEMBL2181983)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant BACE1 using NH-SEVNLAAEF-COOH as substrate after 30 mins by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed