BDBM50437407 CHEMBL2408789::US9023865, 6
SMILES C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1
InChI Key InChIKey=GDJUXJPRTHOKJJ-CQSZACIVSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50437407
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 0.205nMAssay Description:Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.152nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 0.204nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK in human A375 cells assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK in human A375 cells assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair