BDBM50445253 CHEMBL1232500

SMILES CCN1C(Sc2ccc(O)cc12)=CC(C)=O

InChI Key InChIKey=GCSZJMUFYOAHFY-UHFFFAOYSA-N

Data  1 KI  17 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50445253   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataKi:  180nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataKd:  1.64E+3nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system after 10 mins in presence of [gamma33P-ATP] ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair

Target InfoMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  2.99E+3nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  315nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  4.79E+3nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  371nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  240nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  240nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  189nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  226nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  83nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  894nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataKd:  13nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataKd:  1.30nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  240nMAssay Description:Inhibition of Dyrk1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50445253(CHEMBL1232500)Copy SMILESCopy InChI

Affinity DataIC50:  240nMAssay Description:Competitive inhibition of DYRK1A (unknown origin) using ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI