BDBM50448644 CHEMBL3127513::US10696692, Example 149

SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1COC1)c1cc2ccncc2o1

InChI Key InChIKey=OGDYOHGOSNSDAE-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50448644   

TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448644(CHEMBL3127513 | US10696692, Example 149)
Affinity DataIC50:  28nMAssay Description:Inhibition of C-terminal His-tagged human full-length NAMPT expressed in Escherichia coli Rosetta DE3 using nicotinamide as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448644(CHEMBL3127513 | US10696692, Example 149)
Affinity DataIC50:  28.3nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448644(CHEMBL3127513 | US10696692, Example 149)
Affinity DataKd:  80nMAssay Description:Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed