BDBM50461386 CHEMBL4225828

SMILES CNC(=O)c1ccc(Sc2cccc(NC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)nc1

InChI Key InChIKey=QMRSZKRJQUFALC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50461386   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50:  596nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50:  17nMAssay Description:Inhibition of B-Raf (unknown origin) using MEK1 as substrate measured after 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50:  63nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50:  781nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461386(CHEMBL4225828)
Affinity DataIC50:  16nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) using MEK1 as substrate measured after 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed