BDBM50493386 CHEMBL2425737

SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)CCOc4ccccc4)cc23)c1

InChI Key InChIKey=FCAVKAMZQCESHE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50493386   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50493386(CHEMBL2425737)
Affinity DataIC50:  19nMAssay Description:Inhibition of wild type human EGFR tyrosine kinase assessed as Ulight-CAGAGAIETDKEYYTVKD phosphorylation after 15 mins by time-resolved fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50493386(CHEMBL2425737)
Affinity DataIC50:  38nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50493386(CHEMBL2425737)
Affinity DataIC50:  22nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed