BDBM50503649 CHEMBL4476113

SMILES CC1(CC1)c1cc(NCC(=O)N2CCN(CC2)C2CN(C2)C(=O)C=C)c(O)cc1Cl

InChI Key InChIKey=IPFOCHMOYUMURK-UHFFFAOYSA-N

Data  3 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50503649   

TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataKi:  2.00E+5nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells incubated for 6 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant full length FLAG tagged KRAS G12C mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of KRas G12C mutant in human H358 cells assessed as reduction in ERK phosphorylation at T202/Y204 residue incubated for 24 hrs by immunobl...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataIC50:  1.60E+3nMAssay Description:Covalent inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as loss of C12 tryptic peptide of KRAS G12C mutant measured after 6 hrs by L...More data for this Ligand-Target Pair