BDBM50543343 CHEMBL4637298

SMILES [H][C@@]12COC[C@]1([H])[C@@H]2NC(=O)c1cc2[C@@H]([C@@H](CF)Oc2c(c1)C(=O)NC)c1ccccc1

InChI Key InChIKey=WZQLVEPIBAOOGF-UJMXGEILSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50543343   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543343(CHEMBL4637298)
Affinity DataIC50:  2.51E+4nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant (unknown origin) after 30 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543343(CHEMBL4637298)
Affinity DataIC50:  16nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant (unknown origin) after 30 mins by TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543343(CHEMBL4637298)
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543343(CHEMBL4637298)
Affinity DataKd:  34nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543343(CHEMBL4637298)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed