BDBM50551189 CHEMBL4761880
SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)cc1
InChI Key InChIKey=ZBKTZKKFSWSOOE-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50551189
TargetHistone deacetylase 1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human recombinant HDAC1 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 10 mins followed by addition of substrate fluor De Lys green measured after 30 mins by fluores...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 complex preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measure...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human recombinant HDAC6 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK7/cyclin H1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 8.63E+3nMAssay Description:Inhibition of recombinant human full length CDK1/cyclin A2 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human full length CDK2/cyclin A2 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK4/cyclin D1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK6/cyclin D3 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human recombinant HDAC8 preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescent plate reader anal...More data for this Ligand-Target Pair