BDBM50564376 CHEMBL4781229::US11370779, Compound 4

SMILES COC(=O)c1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCN3CCNCC3)c2c1

InChI Key InChIKey=HHKOKFHTWVYTJK-NXGRKYSHSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50564376   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human FLT3 using peptide substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  3nMAssay Description:The inhibition of the FLT3 kinase activity was measured with homogeneous, time-resolved fluorescence (HTRF) assays. Recombinant proteins containing t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  3nMAssay Description:The inhibition of the FLT3 kinase activity was measured with homogeneous, time-resolved fluorescence (HTRF) assays. Recombinant proteins containing t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  239nMAssay Description:Inhibition of c-met (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Gwangju Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  690nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  523nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed