BDBM50618767 CHEMBL5422094

SMILES CS(=O)(=O)c1c2c(c(s1)OC3CCCCC3)CC([C@H]2O)(F)F

InChI Key InChIKey=VVRLYNNVBDMZCH-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50618767   

TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618767(CHEMBL5422094)
Affinity DataKd:  1.25E+5nMAssay Description:Binding affinity to human recombinant HIF-2alpha (240 to 350 residues) assessed as as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618767(CHEMBL5422094)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfected with HRE-luc2P assessed as decrease in luminescence incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618767(CHEMBL5422094)
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells assessed as decrease in VEGF production incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)