BDBM555133 US11339157, Example 27

SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OCC(F)F

InChI Key InChIKey=ZHOAUQGVTFCFCN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 555133   

TargetEpidermal growth factor receptor [669-770,'SVD',771-1210](Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM555133(US11339157, Example 27)
Affinity DataIC50:  7.09nMAssay Description:Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [669-770,'SVD',771-1210](Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM555133(US11339157, Example 27)
Affinity DataIC50:  2.14nMAssay Description:Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent