BDBM575937 5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl]-5H-pyrrolo[2,3- b]pyrazin-7-yl}-4- chloro-3,3-difluoro-2,3- dihydro-1H-indol-2-one, dihydrochloride salt::US11466016, Example 66

SMILES N[C@@H]1C[C@@H]2CC[C@H](C1)N2c1cnc2c(c[nH]c2n1)-c1ccc2NC(=O)C(F)(F)c2c1Cl

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575937   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575937(5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl...)
Affinity DataIC50:  4.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent