BDBM601946 4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 46::US20240150369, Compound 46

SMILES CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21

InChI Key InChIKey=RWSCYFXGWJPUQX-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601946   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-H/Cyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  723nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  22nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  83nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  13nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  723nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  22nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  83nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  14nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  13nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent

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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601946(4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- py...)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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