BDBM7755 4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8-tetraen-12-ylidene]methyl}amino)-N-(pyridin-2-yl)benzene-1-sulfonamide::Other, 22::Oxindole-Based Inhibitor 91

SMILES O=C1Nc2ccc3ncsc3c2C1C=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1

InChI Key InChIKey=SIPNIVSCAYGONU-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7755   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  100nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  9.70nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische UniversitÄT Dortmund

LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Rational Discovery

Curated by ChEMBL
LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  9nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Rational Discovery

Curated by ChEMBL
LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  9.70nMAssay Description:Evaluated for inhibition of human cyclin dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM7755(4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0....)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair