BDBM86644 BC11-38-2::US9173884, BC11-38-2

SMILES CCC(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1

InChI Key InChIKey=UWXVMIBCJRNBBP-UHFFFAOYSA-N

Data  23 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 86644   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholin...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails PubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  1.84E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcAMP specific phosphodiesterase variant PDE4A-10(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  2.33E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoMMDB
UniProtKB/TrEMBL
B.MOADGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  5.12E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  5.00E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Boston College

US Patent

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetIsoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)(Homo sapiens (Human))
Boston College

US Patent

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  8.40E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Boston College

US Patent

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
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TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Homo sapiens (Human))
Boston College

US Patent

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  2.33E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  5.12E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50:  5.00E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Boston College

LigandBDBM86644(BC11-38-2 | US9173884, BC11-38-2)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI