KEGG   Homo sapiens (human): 836
Entry
836               CDS       T01001                                 
Symbol
CASP3, CPP32, CPP32B, SCA-1
Name
(RefSeq) caspase 3
  KO
K02187  caspase 3 [EC:3.4.22.56]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04115  p53 signaling pathway
hsa04148  Efferocytosis
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04623  Cytosolic DNA-sensing pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa04726  Serotonergic synapse
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05222  Small cell lung cancer
hsa05416  Viral myocarditis
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06524  Apoptosis
nt06528  Calcium signaling
nt06535  Efferocytosis
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00101  DCC-apoptotic pathway
N00102  Loss of DCC to DCC-apoptotic pathway
N00145  Extrinsic apoptotic pathway
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N00165  KSHV vIAP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478  EBV BARF1 to intrinsic apoptotic pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00967  VGCC-Ca2+ -apoptotic pathway
N00983  Mutation-caused aberrant Htt to extrinsic apoptotic pathway
N00984  mGluR5-Ca2+ -apoptotic pathway
N00985  Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987  Mutation-caused aberrant Htt to transport of calcium
N01002  Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01005  Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01007  Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01031  Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01047  Mutation-activated LRRK2 to intrinsic apoptotic pathway
N01048  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01049  Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01135  Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01199  Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200  Scrapie conformation PrPSc to transport of calcium
N01747  Find-me signal (nucleotide)
N01748  Find-me signal (LPC)
N01749  Find-me signal (CX3CL1)
N01750  Find-me signal (S1P)
N01754  Activation of XKR8
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    836 (CASP3)
   04668 TNF signaling pathway
    836 (CASP3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    836 (CASP3)
  09143 Cell growth and death
   04210 Apoptosis
    836 (CASP3)
   04215 Apoptosis - multiple species
    836 (CASP3)
   04115 p53 signaling pathway
    836 (CASP3)
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    836 (CASP3)
   04650 Natural killer cell mediated cytotoxicity
    836 (CASP3)
   04657 IL-17 signaling pathway
    836 (CASP3)
  09156 Nervous system
   04726 Serotonergic synapse
    836 (CASP3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    836 (CASP3)
   05206 MicroRNAs in cancer
    836 (CASP3)
   05205 Proteoglycans in cancer
    836 (CASP3)
   05203 Viral carcinogenesis
    836 (CASP3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    836 (CASP3)
   05222 Small cell lung cancer
    836 (CASP3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    836 (CASP3)
   05161 Hepatitis B
    836 (CASP3)
   05160 Hepatitis C
    836 (CASP3)
   05164 Influenza A
    836 (CASP3)
   05162 Measles
    836 (CASP3)
   05168 Herpes simplex virus 1 infection
    836 (CASP3)
   05163 Human cytomegalovirus infection
    836 (CASP3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    836 (CASP3)
   05169 Epstein-Barr virus infection
    836 (CASP3)
   05165 Human papillomavirus infection
    836 (CASP3)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    836 (CASP3)
   05130 Pathogenic Escherichia coli infection
    836 (CASP3)
   05132 Salmonella infection
    836 (CASP3)
   05133 Pertussis
    836 (CASP3)
   05134 Legionellosis
    836 (CASP3)
   05152 Tuberculosis
    836 (CASP3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    836 (CASP3)
   05145 Toxoplasmosis
    836 (CASP3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    836 (CASP3)
   05012 Parkinson disease
    836 (CASP3)
   05014 Amyotrophic lateral sclerosis
    836 (CASP3)
   05016 Huntington disease
    836 (CASP3)
   05020 Prion disease
    836 (CASP3)
   05022 Pathways of neurodegeneration - multiple diseases
    836 (CASP3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    836 (CASP3)
   05416 Viral myocarditis
    836 (CASP3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    836 (CASP3)
   04932 Non-alcoholic fatty liver disease
    836 (CASP3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    836 (CASP3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    836 (CASP3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    836 (CASP3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     836 (CASP3)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C14: caspase family
   836 (CASP3)
SSDB
Motif
Pfam: Peptidase_C14 SICA_beta
Other DBs
NCBI-GeneID: 836
NCBI-ProteinID: NP_004337
OMIM: 600636
HGNC: 1504
Ensembl: ENSG00000164305
UniProt: P42574
Structure
Position
4:complement(184627696..184649447)
AA seq 277 aa
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
NT seq 834 nt   +upstreamnt  +downstreamnt
atggagaacactgaaaactcagtggattcaaaatccattaaaaatttggaaccaaagatc
atacatggaagcgaatcaatggactctggaatatccctggacaacagttataaaatggat
tatcctgagatgggtttatgtataataattaataataagaattttcataaaagcactgga
atgacatctcggtctggtacagatgtcgatgcagcaaacctcagggaaacattcagaaac
ttgaaatatgaagtcaggaataaaaatgatcttacacgtgaagaaattgtggaattgatg
cgtgatgtttctaaagaagatcacagcaaaaggagcagttttgtttgtgtgcttctgagc
catggtgaagaaggaataatttttggaacaaatggacctgttgacctgaaaaaaataaca
aactttttcagaggggatcgttgtagaagtctaactggaaaacccaaacttttcattatt
caggcctgccgtggtacagaactggactgtggcattgagacagacagtggtgttgatgat
gacatggcgtgtcataaaataccagtggaggccgacttcttgtatgcatactccacagca
cctggttattattcttggcgaaattcaaaggatggctcctggttcatccagtcgctttgt
gccatgctgaaacagtatgccgacaagcttgaatttatgcacattcttacccgggttaac
cgaaaggtggcaacagaatttgagtccttttcctttgacgctacttttcatgcaaagaaa
cagattccatgtattgtttccatgctcacaaaagaactctatttttatcactaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (46)   
   KEGG PATHWAY (46)   
Network (55)   
   KEGG NETWORK (55)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (37)   
   RefSeq(nuc) (17)   
   GenBank (10)   
   EMBL (10)   
3D Structure (103)   
   PDB (103)   
Protein domain (2)   
   Pfam (2)   
All databases (285)   

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