2Q6B: Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors

PDB ID: 2Q6BDownload
MMDB ID: 47524
PDB Deposition Date: 2007/6/4
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2Q6B: tetrameric; determined by author and by software (PISA)
Molecular Components in 2Q6B
Label Count Molecule
Proteins (4 molecules)
4
3-hydroxy-3-methylglutaryl-coenzyme a Reductase
(Gene symbol: HMGCR)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
SULFATE IONSULFATE ION
2
4
(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303