Abstract
Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.
MeSH terms
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Animals
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Drug Evaluation, Preclinical
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Guanidine / analogs & derivatives*
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Guanidine / chemical synthesis*
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Guanidine / pharmacology*
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Mice
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Mice, Inbred DBA
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Sodium Channel Blockers*
Substances
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Sodium Channel Blockers
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Guanidine