Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency

Michela I Simone; Adam Wood; David Campkin; Milton J Kiefel; Todd A Houston

doi:10.1016/j.ejmech.2022.114282

Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency

Eur J Med Chem. 2022 May 5:235:114282. doi: 10.1016/j.ejmech.2022.114282. Epub 2022 Mar 20.

Authors

Michela I Simone¹, Adam Wood², David Campkin², Milton J Kiefel³, Todd A Houston⁴

Affiliations

¹ Discipline of Chemistry, University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Drug Design, University of Newcastle, Callaghan, NSW, 2308, Australia. Electronic address: michela_simone@yahoo.co.uk.
² Discipline of Chemistry, University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Drug Design, University of Newcastle, Callaghan, NSW, 2308, Australia.
³ Institute for Glycomics, And the School of Environment and Science, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia.
⁴ Institute for Glycomics, And the School of Environment and Science, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia. Electronic address: t.houston@griffith.edu.au.

PMID: 35367706
DOI: 10.1016/j.ejmech.2022.114282

Abstract

This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.

Keywords: 1-Deoxynojirimycin; Benzimidazole; Chalcone; Cinnamic acid; Coumarin; Flavonoid; Glycosidase; Iminosugar; Natural product; Phthalimide; Terpenoid; Xanthone.

Publication types

Review

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Glycoside Hydrolases*
Imino Sugars* / chemistry
Imino Sugars* / pharmacology

Substances

Enzyme Inhibitors
Imino Sugars
Glycoside Hydrolases