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Found 585 with Last Name = 'yang' and Initial = 'a'
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM36548(N-[1-(7-{bis[(4-methoxyphenyl)methyl]amino}heptyl)...)
Affinity DataKi:  0.690nM ΔG°:  -53.2kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327904(2-amino-4-methyl-6-(1H-pyrazol-3-yl)-8-(tetrahydro...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327907(CHEMBL1257295 | trans-2-amino-8-(4-hydroxycyclohex...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM36547(N-[4,5-dihydroxy-6-(hydroxymethyl)-1-(7-{[(4-metho...)
Affinity DataKi:  1.20nM ΔG°:  -51.8kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101546(US8530494, 211 | US8530652, 125 | US8530652, 73)
Affinity DataKi:  1.60nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101542(US8530494, 207 | US8530652, 121 | US8530652, 69)
Affinity DataKi:  1.90nM EC50:  3nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM36546(N-[1-(7-aminoheptyl)-4,5-dihydroxy-6-(hydroxymethy...)
Affinity DataKi:  2.10nM ΔG°:  -50.4kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389112(CHEMBL2064556)
Affinity DataKi:  2.80nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101479(US8524710, 56 | US8530652, 50 | US8530652, 6)
Affinity DataKi:  2.80nM EC50:  0.940nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101537(US8530494, 204 | US8530652, 115 | US8530652, 64)
Affinity DataKi:  3nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataKi:  3.40nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM4838(US8524710, 83 | US8530494, 13 | US8530652, 52)
Affinity DataKi:  3.5nM EC50:  19nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM4838(US8524710, 83 | US8530494, 13 | US8530652, 52)
Affinity DataKi:  3.5nM EC50:  19nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101547(US8530494, 212 | US8530652, 126 | US8530652, 74)
Affinity DataKi:  3.60nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327894(2-amino-8-isopropyl-6-(6-methoxypyridin-3-yl)-4-me...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327906(2-amino-4-methyl-6-(6-methylpyridin-3-yl)-8-(tetra...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327903(CHEMBL1258910 | trans-2-amino-8-(4-(2-hydroxyethox...)
Affinity DataKi:  5.11nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101548(US8530494, 108 | US8530652, 127 | US8530652, 75)
Affinity DataKi:  5.20nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101544(US8530494, 105 | US8530652, 123 | US8530652, 71)
Affinity DataKi:  5.20nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataKi:  6nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327897(2-amino-8-isopropyl-4-methyl-6-(1H-pyrazol-5-yl)pt...)
Affinity DataKi:  6nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101541(US8530494, 104 | US8530652, 120 | US8530652, 68)
Affinity DataKi:  6.70nM EC50:  20nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327905(CHEMBL1257177 | trans-2-amino-8-((1r,4r)-4-hydroxy...)
Affinity DataKi:  6.80nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101504(US8524699, 91 | US8524710, 82 | US8530652, 31)
Affinity DataKi:  7.20nM EC50:  21nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101549(US8530494, 109 | US8530652, 128 | US8530652, 76)
Affinity DataKi:  8.30nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101543(US8530494, 206 | US8530652, 122 | US8530652, 70)
Affinity DataKi:  8.80nM EC50:  1.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327896(2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4...)
Affinity DataKi:  9nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101476(US8524710, 53 | US8530652, 3 | US8530652, 47)
Affinity DataKi:  11nM EC50:  16nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389116(CHEMBL2064561)
Affinity DataKi:  12nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389117(CHEMBL2064562)
Affinity DataKi:  13nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101530(US8530494, 29 | US8530494, 7 | US8530652, 57)
Affinity DataKi:  14nM EC50:  2.5nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101475(US8524710, 52 | US8530652, 2 | US8530652, 46)
Affinity DataKi:  14nM EC50:  36nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101535(US8530494, 104 | US8530652, 113 | US8530652, 62)
Affinity DataKi:  15nM EC50:  15nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101515(US8524699, 26 | US8530652, 42 | US8530670, 31)
Affinity DataKi:  16nM EC50:  340nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101545(US8530494, 107 | US8530652, 124 | US8530652, 72)
Affinity DataKi:  16nM EC50:  4.40nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101513(US8524699, 18 | US8530652, 40 | US8530652, 85)
Affinity DataKi:  18nM EC50:  98nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101524(US8530652, 51 | US8530652, 96)
Affinity DataKi:  18nM EC50:  31nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327901(2-amino-8-isopropyl-6-(2-methoxypyrimidin-5-yl)-4-...)
Affinity DataKi:  18nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101504(US8524699, 91 | US8524710, 82 | US8530652, 31)
Affinity DataKi:  20nM EC50:  103nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataKi:  20nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101507(US8524710, 86 | US8530652, 34 | US8530652, 79)
Affinity DataKi:  21nM EC50:  778nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101534(US8530494, 202 | US8530652, 112 | US8530652, 61)
Affinity DataKi:  22nM EC50:  19nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101514(US8524699, 22 | US8530652, 41 | US8530652, 86)
Affinity DataKi:  24nM EC50:  147nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101518(US8524699, 46 | US8530652, 45 | US8530652, 90)
Affinity DataKi:  25nM EC50:  32nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM36549(N-{7-[5-acetamido-3,4-dihydroxy-2-(hydroxymethyl)p...)
Affinity DataKi:  26.7nM ΔG°:  -44.0kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389113(CHEMBL2064558)
Affinity DataKi:  30nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327900(2-amino-8-isopropyl-6-(6-methoxypyridin-3-yl)-4-me...)
Affinity DataKi:  30nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM50389120(CHEMBL2064565)
Affinity DataKi:  31nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101639(US8530652, 84)
Affinity DataKi:  34nM EC50:  455nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Agouron Pharmaceuticals

US Patent
LigandPNGBDBM101485(US8524710, 62 | US8530652, 12 | US8530652, 56)
Affinity DataKi:  38nM EC50:  78nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
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