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Found 1091 with Last Name = 'cox' and Initial = 'b'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM356652(US10213433, Compound 34 | US11369599, Compound 34 ...)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  0.0440nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  0.0550nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50021325(4-methyl-(1S,5R,13R,14S)-12-oxa-4-azapentacyclo[9....)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOpioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOpioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(MOUSE)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  1.83nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50021325(4-methyl-(1S,5R,13R,14S)-12-oxa-4-azapentacyclo[9....)
Affinity DataKi:  1.94nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
Affinity DataKi:  2.15nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50150766((2R,3R,4S,5R)-2-(6-amino-2-((S)-1-hydroxy-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  2.34nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2.69nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50390424(CHEMBL2071340)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant GST-tagged PI3K p110delta using [32P]ATP after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-arrestin-1(RABBIT)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
Affinity DataKi:  3.60nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(MOUSE)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
In DepthDetails PubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50233524(CHEMBL3981414)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50390409(CHEMBL1986603)
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant GST-tagged PI3K p110delta using [32P]ATP after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309479(CHEMBL591423 | N-((2S,3S,4R,5R)-5-(6-(2,2-diphenyl...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  4.80nMMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50390408(CHEMBL2071338)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant GST-tagged PI3K p110alpha by KinaseGlo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309478(CHEMBL601514 | N-((2S,3S,4R,5R)-5-(2-(2-(1H-imidaz...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309480(CHEMBL591356 | N-((2S,3S,4R,5R)-5-(6-(2,2-diphenyl...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309494((1R,2S,3R,5S)-3-(2-(2-(1-ethyl-1H-imidazol-4-yl)et...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309481(CHEMBL592541 | N-((2S,3S,4R,5R)-5-(2-(2-(1-ethyl-1...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50233523(CHEMBL3931906)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
In DepthDetails PubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50233522(CHEMBL3932668)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
Affinity DataKi:  7.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309487(CHEMBL601515 | N-((2S,3S,4R,5R)-5-(6-(2,2-diphenyl...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309482(CHEMBL592540 | N-((2S,3S,4R,5R)-3,4-dihydroxy-5-(2...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  8.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOpioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  9.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin D2 receptor 2(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442299(CHEMBL2442750)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-prostaglandin D2 from mouse CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50390426(CHEMBL2071329)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant GST-tagged PI3K p110alpha by KinaseGlo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM81934(Beta-Endorphin)
Affinity DataKi:  12.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50021325(4-methyl-(1S,5R,13R,14S)-12-oxa-4-azapentacyclo[9....)
Affinity DataKi:  13.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  13.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOpioid receptor delta 1(Bos taurus)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM81934(Beta-Endorphin)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM356652(US10213433, Compound 34 | US11369599, Compound 34 ...)
Affinity DataKi:  14nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  14.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  15.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50309486(CHEMBL589348 | N-((2S,3S,4R,5R)-5-(6-(2,2-diphenyl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in Sf21 cells co-expressing GalphaS2, beta4, gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM82090(DALLE)
Affinity DataKi:  16.4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
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